High-Resolution Measurement of Shear Mechanical Properties in Articular Cartilage Using GRATE and WAND
Local mechanical properties in articular cartilage and other biological tissues are typically measured by tracking the displacement of cells, cell nuclei and other fiducial markers using particle image velocimetry (PIV) and other feature-tracking methods (see "Quasi-Static Shear Mechanical Properties of Articular Cartilage"). However, these techniques are limited in spatial resolution by the density of trackable markers. In adult articular cartilage, intervertebral disk and other soft tissues, cells can be very sparse. Therefore, we have developed grid-resolution automated tissue elastog